TGFβ family signaling: novel insights in development and disease
Author:
Wharton Kristi1, Derynck Rik2
Affiliation:
1. Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. 2. Department of Cell and Tissue Biology, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA 94143, USA.
Abstract
Advances in our understanding of the many levels of regulation of TGFβand BMP signaling were reported at the recent FASEB Summer Conference entitled`The TGFβ Superfamily: Development and Disease', which was held in Carefree, Arizona, USA, on the northern edge of the Sonoran Desert. This conference was the fifth meeting in a biannual FASEB conference series and, as with the previous meetings, brought together biochemists, geneticists,developmental and tissue biologists interested in the inter-workings of TGFβ/BMP signaling pathways and in the consequences of these pathways going awry.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Reference47 articles.
1. Ben-Haim, N., Lu, C., Guzman-Ayala, M., Pescatore, L., Mesnard,D., Bischofberger, M., Naef, F., Robertson, E. J. and Constam, D. B.(2006). The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev. Cell11,313-323. 2. Bierie, B., Chung, C. H., Parker, J. S., Stover, D. G., Cheng,N., Chytil, A., Aakre, M., Shyr, Y. and Moses, H. L. (2009). Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest.119,1571-1582. 3. Chang, C. (2008). Agonists and antagonists of the TGF-β family. In The TGF-β Family, vol.50 (ed. R. Derynck and K. Miyazono), pp.203-258. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. 4. Cui, Y., Hackenmiller, R., Berg, L., Jean, F., Nakayama, T.,Thomas, G. and Christian, J. (2001). The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. Genes Dev.15,2797-2802. 5. Daly, A. C., Randall, R. A. and Hill, C. S.(2008). Transforming growth factor β-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol. Cell. Biol.28,6889-6902.
Cited by
102 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|