Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions
Author:
Affiliation:
1. Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5Z 4B4, Canada
2. Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, Ontario M5S 3E2, Canada
Funder
University of Toronto
Simon Fraser University
Institute of Musculoskeletal Health and Arthritis
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada
British Columbia Government Leading Edge Endowment Fund
Canadian Foundation for Innovation
Publisher
American Chemical Society (ACS)
Subject
Pharmacology (medical),Pharmacology
Link
https://pubs.acs.org/doi/pdf/10.1021/acsptsci.1c00027
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4. Billot, X., Young, R. N., and Han, Y. (2003) 1,5-Distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma, WO2003103772A1.
5. Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis
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