Rational Drug Design of Targeted and Enzyme-Cleavable Vitamin E Analogs as a Neoadjuvant to Chemotherapy: <i>In Vitro</i> and <i>In Vivo</i> Evaluation on Reduction of the Cardiotoxicity Side Effect of Doxorubicin-Reference-Cited by-同舟云学术

Rational Drug Design of Targeted and Enzyme-Cleavable Vitamin E Analogs as a Neoadjuvant to Chemotherapy: In Vitro and In Vivo Evaluation on Reduction of the Cardiotoxicity Side Effect of Doxorubicin

Published:2023-02-06 Issue:3 Volume:6 Page:372-386
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Pandurangi Raghu S.¹^ORCID,Cseh Orsolya²,Luchman Hema Artee²,Ma Cynthia Xiuguang³,Senadheera Sanjeewa N.⁴,Forrest Marcus Laird⁴^ORCID

Affiliation:

1. Sci-Engi-Medco Solutions Inc. (SEMCO), 573, Lexington Landing Pl, St. Charles, Missouri 63303, United States

2. HRIC 2A25, 3330 Hospital Drive NW, Calgary, AB T2N 4N, Canada

3. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States

4. Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States

Funder

National Cancer Institute

SEMCO

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00091

Reference54 articles.

1. Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

2. Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

3. The tumor strikes back: New data on expression of the CD95(APO-1/Fas) receptor/ligand system may cause paradigm changes in our view on drug treatment and tumor immunology

4. NF- B activation in human breast cancer specimens and its role in cell proliferation and apoptosis

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