Direct and Precise Measurement of Bevacizumab Levels in Human Plasma Based on Controlled Methionine Oxidation and Multiple Reaction Monitoring

Author:

Gaspar Vanessa P.1,Ibrahim Sahar1,Sobsey Constance A.1,Richard Vincent R.2,Spatz Alan3,Zahedi René P.24,Borchers Christoph H.14ORCID

Affiliation:

1. Gerald Bronfman Department of Oncology, Jewish General Hospital, and Segal Cancer Proteomics Center, Lady Davis Institute, General Hospital, McGill University, Montreal, Quebec H3T1E2, Canada

2. Segal Cancer Proteomics Center, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec H3T1E2, Canada

3. Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec H3T1E2, Canada

4. Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia

Funder

McGill University

Genome Canada

Terry Fox Research Institute

Warren Y. Soper Charitable Trust

Alvin Segal Family Foundation

Ministry of Science and Higher Education of the Russian Federation

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Reference43 articles.

1. A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer

2. Duffy, A. M., Bouchier-Hayes, D. J., and Harmey, J. H. (2013) Vascular endothelial growth factor (VEGF) and its role in non-endothelial cells: autocrine signalling by VEGF, in Madame Curie Bioscience Database [Internet], Landes Bioscience, https://www.ncbi.nlm.nih.gov/books/NBK6482/.

3. VEGFA Upregulates FLJ10540 and Modulates Migration and Invasion of Lung Cancer via PI3K/AKT Pathway

4. Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells

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