Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil-Reference-Cited by-同舟云学术

Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil

Published:2022-02-09 Issue:7 Volume:7 Page:6046-6052
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Kurasaka Chinatsu¹,Nishizawa Nana¹,Ogino Yoko¹²,Sato Akira¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

2. Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c06394

Reference36 articles.

1. 5-Fluorouracil: mechanisms of action and clinical strategies

2. 5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

3. Fluorinated Pyrimidines

4. Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

5. Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

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