Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth-Reference-Cited by-同舟云学术

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

Published:2021-01-13 Issue:3 Volume:6 Page:2284-2311
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Ray Peter C.¹,Huggett Margaret¹,Turner Penelope A.¹,Taylor Malcolm¹,Cleghorn Laura A. T.¹,Early Julie²,Kumar Anuradha²,Bonnett Shilah A.²,Flint Lindsay²,Joerss Douglas²,Johnson James²,Korkegian Aaron²,Mullen Steven²,Moure Abraham L.¹,Davis Susan H.¹,Murugesan Dinakaran¹,Mathieson Michael¹,Caldwell Nicola¹,Engelhart Curtis A.³,Schnappinger Dirk³,Epemolu Ola¹,Zuccotto Fabio¹,Riley Jennifer¹,Scullion Paul¹,Stojanovski Laste¹,Massoudi Lisa⁴,Robertson Gregory T.⁴,Lenaerts Anne J.⁴,Freiberg Gail⁵,Kempf Dale J.⁵^ORCID,Masquelin Thierry⁶,Hipskind Philip A.⁷,Odingo Joshua²,Read Kevin D.¹^ORCID,Green Simon R.¹^ORCID,Wyatt Paul G.¹^ORCID,Parish Tanya²^ORCID

Affiliation:

1. Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

2. TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Avenue East, Suite 400, Seattle, Washington 98102, United States

3. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States

4. Mycobacteria Research Laboratories, Colorado State University, 200 W. Lake Street, Fort Collins, Colorado 80523-1682, United States

5. AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

6. Discovery Chemistry Research, Eli Lilly and Company, Lilly Corporate Centre, MC/87/02/203, G17, Indianapolis, Indiana 46285, United States

7. Lgenia Inc., Fortville, Indiana 46040, United States

Funder

U.S. Department of Health and Human Services

Bill and Melinda Gates Foundation

Wellcome Trust

Eli Lilly and Company

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.0c05589

Reference44 articles.

1. Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe

2. WHO. Global Tuberculosis Report 2020; World Health Organization: Geneva (Switzerland), 2020; ISBN 978-92-4-001313-1.

3. The WHO 2014 Global tuberculosis report—further to go

4. Tuberculosis

5. Treatment of Tuberculosis

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