Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution-Reference-Cited by-同舟云学术

Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

Published:2019-10-02 Issue:16 Volume:4 Page:16943-16955
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Shibuya Kimiyuki¹^ORCID,Morikawa Shigeru¹,Miyamoto Masayoshi¹,Ogawa Shin-ichiro¹,Tsunenari Yoshihiko¹,Urano Yasuomi²,Noguchi Noriko²

Affiliation:

1. Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., 2-17-43, Noguchicho, Higashimurayama, Tokyo 189-0022, Japan

2. Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan

Funder

Japan Science and Technology Agency

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02307

Reference65 articles.

1. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

2. ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase

3. Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes

4. Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines

5. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates

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