A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA-Reference-Cited by-同舟云学术

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

Published:2014-03-10 Issue:4 Volume:9 Page:986-993
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Li Huei-Jiun¹,Lai Cheng-Tsung¹,Pan Pan¹,Yu Weixuan¹,Liu Nina¹,Bommineni Gopal R.¹,Garcia-Diaz Miguel¹,Simmerling Carlos¹,Tonge Peter J.¹

Affiliation:

1. Institute for Chemical Biology and Drug Discovery, ‡Laufer Center for Physical and Quantitative Biology and §Department of Chemistry, ∥Graduate Program in Biochemistry and Structural Biology, and ⊥Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb400896g

Reference53 articles.

1. Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogs

2. Drug–target residence time and its implications for lead optimization

3. Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity

4. Conformational adaptation in drug–target interactions and residence time

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Membrane-assisted tariquidar access and binding mechanisms of human ATP-binding cassette transporter P-glycoprotein;Frontiers in Molecular Biosciences;2024-03-15

2. Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors;Bioorganic Chemistry;2024-02

3. Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA;European Journal of Medicinal Chemistry;2023-11

4. Determination of the Association between Mesotrione Sensitivity and Conformational Change of 4-Hydroxyphenylpyruvate Dioxygenase via Free-Energy Analyses;Journal of Agricultural and Food Chemistry;2023-06-06

5. Evaluating the Impact of the Tyr158 pK_a on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis;Biochemistry;2023-06-04