Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity-Reference-Cited by-同舟云学术

Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity

Published:2009-02-10 Issue:3 Volume:4 Page:221-231
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Lu Hao¹,England Kathleen²,am Ende Christopher¹,Truglio James J.³,Luckner Sylvia⁴,Reddy B. Gopal¹,Marlenee Nicole L.²,Knudson Susan E.²,Knudson Dennis L.²,Bowen Richard A.²,Kisker Caroline⁴,Slayden Richard A.²,Tonge Peter J.¹

Affiliation:

1. Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400

2. Rocky Mountain Regional Center of Excellence and Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682

3. Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794-5115

4. Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb800306y

Reference46 articles.

1. Intracellular survival mechanisms of Francisella tularensis, a stealth pathogen

2. Tularaemia: bioterrorism defence renews interest in Francisella tularensis

3. THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

4. The Enoyl-[Acyl-Carrier-Protein] Reductase (FabI) of Escherichia coli, which Catalyzes a Key Regulatory Step in Fatty Acid Biosynthesis, Accepts NADH and NADPH as Cofactors and is Inhibited by Palmitoyl-CoA

5. Inhibiting Bacterial Fatty Acid Synthesis

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