1. Department of Pharmaceutical Chemistry, University of Pavia, Faculty of Pharmacy, Via Taramelli 12, 27100 Pavia, Italy, Department of Biology, University of Genoa, Medical School, Corso Europa 26, 16132, Genoa, Italy, Department of Experimental and Applied Pharmacology, University of Pavia, Faculty of Pharmacy, Via Taramelli 14, 27100 Pavia, Italy, and Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, Via Ranieri Monte d'Ago, 60131 Ancona, Italy