Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors-Reference-Cited by-同舟云学术

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

Published:2014-11-26 Issue:1 Volume:58 Page:376-400
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pasquier Benoit,El-Ahmad Youssef,Filoche-Rommé Bruno,Dureuil Christine,Fassy Florence,Abecassis Pierre-Yves,Mathieu Magali,Bertrand Thomas,Benard Tsiala,Barrière Cédric,El Batti Samira,Letallec Jean-Philippe,Sonnefraud Véronique,Brollo Maurice,Delbarre Laurence,Loyau Véronique,Pilorge Fabienne,Bertin Luc,Richepin Patrick,Arigon Jérôme¹,Labrosse Jean-Robert¹,Clément Jacques¹,Durand Florence¹,Combet Romain¹,Perraut Pierre¹,Leroy Vincent,Gay Frédéric,Lefrançois Dominique,Bretin François,Marquette Jean-Pierre,Michot Nadine,Caron Anne,Castell Christelle,Schio Laurent,McCort Gary,Goulaouic Hélène,Garcia-Echeverria Carlos,Ronan Baptiste

Affiliation:

1. Lead Generation Candidate Realization (LGCR C&BD), Sanofi, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5013352

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