1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands, Department of Chemical Sciences, Camerino University, via S, Agostino 1, 62032, Camerino (MC), Italy, and Laboratory of General Biochemistry and Physical Chemistry, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, B-9000, Ghent, Belgium