Fluorescence-Based Approach for Detecting and Characterizing Antibiotic-Induced Conformational Changes in Ribosomal RNA:  Comparing Aminoglycoside Binding to Prokaryotic and Eukaryotic Ribosomal RNA Sequences

Author:

Kaul Malvika1,Barbieri Christopher M.1,Pilch Daniel S.1

Affiliation:

1. Contribution from the Department of Pharmacology, University of Medicine and Dentistry of New Jersey−Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854-5635

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference22 articles.

1. Puglisi, J. D.; Blanchard, S. C.; Dahlquist, K. D.; Eason, R. G.; Fourmy, D.; Lynch, S. R.; Recht, M. I.; Yoshizawa, S. InThe Ribosome: Structure, Function, Antibiotics, and Cellular Interactions; Garrett, R. A., Douthwaite, S. R., Liljas, A., Matheson, A. T., Moore, P. B., Noller, H. F., Eds.; ASM Press:  Washington, DC, 2000; pp 419−429.

2. Recognition of the Codon-Anticodon Helix by Ribosomal RNA

3. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

4. Structure of the A Site of Escherichia coli 16 S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

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