Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity-Reference-Cited by-同舟云学术

Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity

Published:2003-12-09 Issue:1 Volume:47 Page:110-122
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ersmark Karolina¹,Feierberg Isabella¹,Bjelic Sinisa¹,Hamelink Elizabeth¹,Hackett Fiona¹,Blackman Michael J.¹,Hultén Johan¹,Samuelsson Bertil¹,Åqvist Johan¹,Hallberg Anders¹

Affiliation:

1. Department of Medicinal Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden, and Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, SE-751 24 Uppsala, Sweden, Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK, and Medivir AB, Lunastigen 7, SE-141 44 Huddinge, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030933g

Reference48 articles.

1. Target-Based Drug Discovery for Malaria, Leishmaniasis, and Trypanosomiasis

2. Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

3. Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.

4. HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM

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