The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents-Reference-Cited by-同舟云学术

The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents

Published:2008-07-08 Issue:15 Volume:51 Page:4589-4600
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Jain Hiteshkumar D.¹,Queener Sherry F.¹,Kisliuk Roy L.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana 46202, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800244v

Reference34 articles.

1. aTaken in part from the dissertation submitted by H.J. to the Graduate School of Pharmaceutical Sciences, Duquesne University, in partial fulfillment of the requirements for the degree of Ph.D., July 2006.

2. bPresented in part at the 229th American Chemical Society National Meeting, San Diego, CA, March 13−17, 2005; Abstract MEDI-491.

3. cPresented in part at the 13th International Symposium on Chemistry and Biology of Pteridines and Folates, Egmond aan Zee, The Netherlands, June 20−24, 2005; Oral Presentation O04-02.

4. dPresented in part at the 13th International Symposium on Chemistry and biology of Pteridines and Folates, Egmond aan Zee, The Netherlands, June 20−24, 2005; Poster number P-09.

5. ePresented in part at the 231st American Chemical Society National Meeting, Atlanta, GA, March 26−30, 2006; Abstr. MEDI-348.

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