Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge-Reference-Cited by-同舟云学术

Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge

Published:2018-05 Issue:9 Volume:26 Page:2674-2685
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Li Hao,Fang Fang,Liu Yunqi,Xue Liangmin,Wang Meng,Guo Ying,Wang Xiaowei,Tian Chao,Liu Junyi,Zhang Zhili

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. The biochemistry of folates. In folate antagonists as therapeutic agents;Kisliuk,1984

2. The renewed potential for folate antagonists in contemporary cancer chemotherapy;Berman;J Med Chem,1991

3. Eukaryotic dihydrofolate reductase;Blakley;Adv Enzymol Mol Biol,1995

4. Anticancer antifolates: current status and futuredirections;McGuire;Curr Pharm Des,2003

5. Molecular basis of antifolate resistance;Assaraf;Cancer Metastasis Rev,2007

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