Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody–Drug Conjugate-Reference-Cited by-同舟云学术

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Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody–Drug Conjugate

Published:2014-12-09 Issue:6 Volume:12 Page:1730-1737
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Hu George¹,Leal Mauricio²,Lin Qingcong³,Affolter Timothy⁴,Sapra Puja⁵,Bates Brian³,Damelin Marc⁵

Affiliation:

1. Drug Safety Research & Development, Pfizer Inc., Pearl River, New York 10965, United States

2. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Pearl River, New York 10965, United States

3. Global Biotherapeutic Technologies, Pfizer Inc., Cambridge, Massachusetts 02139, United States

4. Drug Safety Research & Development, Pfizer Inc., La Jolla, California 92121, United States

5. Oncology Research Unit, Pfizer Inc., Pearl River, New York 10965, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp5006323

Reference29 articles.

1. A 72 kD trophoblast glycoprotein defined by a monoclonal antibody

2. Isolation and characterization of 5T4, a tumour-associated antigen

3. Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia

4. Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells

5. Epithelial-Mesenchymal Transition Events during Human Embryonic Stem Cell Differentiation

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1. Trophoblast glycoprotein is a new candidate gene for Parkinson’s disease;npj Parkinson's Disease;2021-12

2. High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas;Cancers;2021-09-28

3. Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer;Targeted Oncology;2019-07-22

4. Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model;Stem Cell Research;2018-05

5. Preclinical Development of an anti-5T4 Antibody–Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice;Bioconjugate Chemistry;2015-07-16

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