Preclinical Development of an anti-5T4 Antibody–Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice-Reference-Cited by-同舟云学术

Preclinical Development of an anti-5T4 Antibody–Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice

Published:2015-07-16 Issue:11 Volume:26 Page:2223-2232
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Leal Mauricio¹,Wentland JoAnn²,Han Xiaogang²,Zhang Yanhua²,Rago Brian²,Duriga Nicole³,Spriggs Franklin³,Kadar Eugene²,Song Wei²,McNally James³,Shakey Quazi³,Lorello Leslie²,Lucas Judy⁴,Sapra Puja⁴

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Pearl River, New York 10965, United States

2. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States

3. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Andover, Massachusetts 01810, United States

4. Oncology Research Unit, Pfizer Inc., Pearl River, New York 10965, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.5b00205

Reference33 articles.

1. An FDA oncology analysis of antibody-drug conjugates

2. A 72 kD trophoblast glycoprotein defined by a monoclonal antibody

3. Isolation and characterization of 5T4, a tumour-associated antigen

4. The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin

5. Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma

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