Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout-Reference-Cited by-同舟云学术

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Published:2022-10-06 Issue:41 Volume:144 Page:18861-18875
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Steimbach Raphael R.¹²^ORCID,Herbst-Gervasoni Corey J.³^ORCID,Lechner Severin⁴^ORCID,Stewart Tracy Murray⁵^ORCID,Klinke Glynis⁶,Ridinger Johannes⁷⁸,Géraldy Magalie N. E.¹^ORCID,Tihanyi Gergely¹^ORCID,Foley Jackson R.⁵,Uhrig Ulrike⁹^ORCID,Kuster Bernhard⁴^ORCID,Poschet Gernot⁶,Casero Robert A.⁵^ORCID,Médard Guillaume⁴^ORCID,Oehme Ina⁷⁸¹⁰^ORCID,Christianson David W.³^ORCID,Gunkel Nikolas¹¹¹,Miller Aubry K.¹¹¹^ORCID

Affiliation:

1. Cancer Drug Development, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

2. Biosciences Faculty, Heidelberg University, 69120 Heidelberg, Germany

3. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States

4. Chair of Proteomics and Bioanalytics, Technical University of Munich, 85354 Freising, Germany

5. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States

6. Center for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany

7. Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

8. Hopp Children’s Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany

9. Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany

10. Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany

11. German Cancer Consortium (DKTK), 69120 Heidelberg, Germany

Funder

Hector Stiftung

National Cancer Institute

Deutsches Krebsforschungszentrum

Deutsche Forschungsgemeinschaft

Chan Zuckerberg Initiative