Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects-Reference-Cited by-同舟云学术

Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects

Published:2022-08-03 Issue:32 Volume:144 Page:14517-14534
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Guenther Dale C.¹,Mori Shohei¹^ORCID,Matsuda Shigeo¹,Gilbert Jason A.¹,Willoughby Jennifer L. S.¹,Hyde Sarah¹,Bisbe Anna¹,Jiang Yongfeng¹,Agarwal Saket¹,Madaoui Mimouna¹,Janas Maja M.¹,Charisse Klaus¹,Maier Martin A.¹,Egli Martin²^ORCID,Manoharan Muthiah¹^ORCID

Affiliation:

1. Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States

2. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c01679

Reference82 articles.

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5. Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

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