Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors-Reference-Cited by-同舟云学术

Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors

Published:1999-08-26 Issue:19 Volume:42 Page:3809-3820
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Marsham Peter R.¹,Wardleworth J. Michael¹,Boyle F. Thomas¹,Hennequin Laurent F.¹,Kimbell Rosemary¹,Brown Melody¹,Jackman Ann L.¹

Affiliation:

1. AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, England, AstraZeneca, Centre de recherches, Z. I. La Pompelle, BP 401, 51064 Reims, France, and Drug Development Section, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9803727

Reference37 articles.

1. Jackman, A. L.; Jodrell, D. I.; Gibson, W.; Stephens, T. C. InPurine andPyrimidine Metabolism in Man; Harkness, R. A., et al., Eds.; Plenum Press: New York, 1991; pp 19−23.

2. A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717.

3. ‘Tomudex’ (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia

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