Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity-Reference-Cited by-同舟云学术

Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity

Published:2007-05-08 Issue:12 Volume:50 Page:2767-2778
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kasibhatla Srinivas R.¹,Hong Kevin¹,Biamonte Marco A.¹,Busch David J.¹,Karjian Patricia L.¹,Sensintaffar John L.¹,Kamal Adeela¹,Lough Rachel E.¹,Brekken John¹,Lundgren Karen¹,Grecko Roy¹,Timony Gregg A.¹,Ran Yingqing¹,Mansfield Robert¹,Fritz Lawrence C.¹,Ulm Edgar¹,Burrows Francis J.¹,Boehm Marcus F.¹

Affiliation:

1. Departments of Chemistry, Molecular Discovery, Pharmacology, Toxicology, Pharmaceutical Development and Oncology R&D, Biogen Idec, Inc., 5200 Research Place, San Diego, CA 92122

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050752%2B

Reference61 articles.

1. Therapeutic and diagnostic implications of Hsp90 activation

2. Inhibitors of HSP90 and other chaperones for the treatment of cancer

3. Heat shock protein 90 as a molecular target for cancer therapeutics

4. HSP90 as a new therapeutic target for cancer therapy: the story unfolds

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