Heat shock protein 90 as a molecular target for cancer therapeutics

Author:

Isaacs Jennifer S,Xu Wanping,Neckers Len

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference41 articles.

1. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts;Baselga;Cancer Res.,1998

2. Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2;Basso;Oncogene,2002

3. The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy;Blagosklonny;Leukemia,2001

4. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins;Connell;Nat. Cell Biol.,2001

5. ATP induces a conformational change of the 90-kDa heat shock protein (hsp90);Csermely;J. Biol. Chem.,1993

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