A Practical Enantioselective Synthesis of Odanacatib, a Potent Cathepsin K Inhibitor, via Triflate Displacement of an α-Trifluoromethylbenzyl Triflate-Reference-Cited by-同舟云学术

A Practical Enantioselective Synthesis of Odanacatib, a Potent Cathepsin K Inhibitor, via Triflate Displacement of an α-Trifluoromethylbenzyl Triflate

Published:2009-01-13 Issue:4 Volume:74 Page:1605-1610
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

O’Shea Paul D.¹,Chen Cheng-yi¹,Gauvreau Danny¹,Gosselin Francis¹,Hughes Greg¹,Nadeau Christian¹,Volante Ralph P.¹

Affiliation:

1. Department of Process Research, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Québec, H9R 4P8, Canada, and Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo8020314

Reference36 articles.

1. Proteolytic Activity of Human Osteoclast Cathepsin K

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3. Cathepsin K inhibitors, 2000 – 2004

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