A Practical Enantioselective Synthesis of Odanacatib, a Potent Cathepsin K Inhibitor, via Triflate Displacement of an α-Trifluoromethylbenzyl Triflate
Author:
Affiliation:
1. Department of Process Research, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Québec, H9R 4P8, Canada, and Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo8020314
Reference36 articles.
1. Proteolytic Activity of Human Osteoclast Cathepsin K
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4. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.
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