Diastereoselective hydride transfer enables a synthesis of chiral 1,5-carboxamido-trifluoromethylcarbinols-Reference-Cited by-同舟云学术

Diastereoselective hydride transfer enables a synthesis of chiral 1,5-carboxamido-trifluoromethylcarbinols

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tinelli Roberto¹²,Schupp Manuel¹³^ORCID,Klose Immo¹,Shaaban Saad¹,Maryasin Boris¹⁴^ORCID,González Leticia¹⁴^ORCID,Maulide Nuno¹³^ORCID

Affiliation:

1. Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria

2. Vienna Doctoral School in Chemistry, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria

3. CeMM – Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria

4. Institute of Theoretical Chemistry, University of Vienna, Währinger Straße 17, 1090 Vienna, Austria

Abstract

The synthesis of enantiopure tertiary trifluoromethylcarbinols (recurrent features in bioactive compounds) was achieved. We report herein a diastereoselective redox-neutral process allowing the synthesis of 1,5-carboxamido-trifluoromethylcarbinols.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC05049E

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