Solubility of Gastrodin in Pure and Mixed Solvents at 273.15–313.15 K and Its Correlation with Different Thermodynamic Models
Author:
Affiliation:
1. School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, P. R. China
2. Industrial Catalysis Institute of Zhejiang University of Technology, Hangzhou 310014, P. R. China
Funder
National Natural Science Foundation of China
Science and Technology Plan Project of Taizhou
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jced.9b00286
Reference24 articles.
1. Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death
2. Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v.
3. Formulation and Evaluation of In Situ Gelling Systems for Intranasal Administration of Gastrodin
4. Role of glucose transporters in the intestinal absorption of gastrodin, a highly water-soluble drug with good oral bioavailability
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5. Equilibrium Solubility and Modeling of Glibenclamide in Cosolvent Mixtures of Methanol, n-Propanol, Isopropanol, and Acetonitrile + WaterYuxiu Li, Yu Zhu, Wanwan Wang, Juan Song, Hua LvCollege of Pharmacy and Chemistry & Chemical Engineering, TaiZhou University, Taizhou, Jiangsu 225300, People’s Republic of ChinaCorresponding author . Tel: + 86 15161061813* E-mail address: yuxiulitzu@163.com ABSTRACTEquilibrium solubility of glibenclamide (GCM) in aqueous solutions of methanol, n-propanol, isopropanol, and acetonitrile were studied by static technique at temperatures ranging from 288.15 K to 323.15 K under p = 101.3 kPa. When the composition of cosolvents was constant in the four mixed solvents, GCM solubility increased with the rising temperature. When the temperature was fixed, the GCM mole fraction solubility showed positive dependence on the increasing mass fraction;SSRN Electronic Journal;2022
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