Equilibrium Solubility and Modeling of Glibenclamide in Cosolvent Mixtures of Methanol, n-Propanol, Isopropanol, and Acetonitrile + WaterYuxiu Li, Yu Zhu, Wanwan Wang, Juan Song, Hua LvCollege of Pharmacy and Chemistry & Chemical Engineering, TaiZhou University, Taizhou, Jiangsu 225300, People’s Republic of ChinaCorresponding author . Tel: + 86 15161061813* E-mail address: yuxiulitzu@163.com ABSTRACTEquilibrium solubility of glibenclamide (GCM) in aqueous solutions of methanol, n-propanol, isopropanol, and acetonitrile were studied by static technique at temperatures ranging from 288.15 K to 323.15 K under p = 101.3 kPa. When the composition of cosolvents was constant in the four mixed solvents, GCM solubility increased with the rising temperature. When the temperature was fixed, the GCM mole fraction solubility showed positive dependence on the increasing mass fraction