Synthesis of a Histamine H3 Receptor Antagonist—Manipulation of Hydroxyproline Stereochemistry, Desymmetrization of Homopiperazine, and Nonextractive Sodium Triacetoxyborohydride Reaction Workup
Author:
Affiliation:
1. Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo100629z
Reference32 articles.
1. The histamine H3 receptor: from gene cloning to H3 receptor drugs
2. Histamine H3 receptor antagonists: From target identification to drug leads
3. Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists
4. Keynote review: Histamine H3 receptor antagonists reach out for the clinic
5. New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists
Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A carbohydrate based straightforward approach to trans-4-hydroxy-d-proline and trans-4-hydroxy-d-prolinol;Tetrahedron Letters;2020-07
2. Pyrrolidine ring puckering and prolyl amide bond configurations of 2-methyl-allo-hydroxyproline-based dipeptides;Organic & Biomolecular Chemistry;2019
3. One-pot synthesis of novel (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl) pyrrolidine-2-carboxamides via $$\hbox {TiO}_{2}$$ TiO 2 -NPs and $$\hbox {Pd}(\hbox {PPh}_{3})_{2}\hbox {Cl}_{2}$$ Pd ( PPh 3 ) 2 Cl 2 catalysts and investigation of their biological activities;Molecular Diversity;2017-02-11
4. Synthesis of 4-hydroxy-2-methylproline derivatives via pyrrolidine ring assembly: chromatographic resolution and diastereoselective synthesis approaches;Tetrahedron: Asymmetry;2016-10
5. A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines;Tetrahedron Letters;2015-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3