Investigation into the Formation of the Genotoxic Impurity Ethyl Besylate in the Final Step Manufacturing Process of UK-369,003-26, a Novel PDE5 Inhibitor-Reference-Cited by-同舟云学术

Investigation into the Formation of the Genotoxic Impurity Ethyl Besylate in the Final Step Manufacturing Process of UK-369,003-26, a Novel PDE5 Inhibitor

Published:2010-06-25 Issue:4 Volume:14 Page:1027-1031
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hajikarimian Yousef¹,Yeo Steve¹,Ryan Robert W.¹,Levett Philip¹,Stoneley Christopher¹,Singh Paul¹

Affiliation:

1. Pfizer Global Research and Development, Chemical Research and Development, and Analytical Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op100141g

Reference17 articles.

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2. Hoog, T. J.d.Request to Assess the Risk of Occurrence of Contamination With Mesilate Esters and Other Related Compounds in Pharmaceuticals;Coordination Group for Mutual Recognition-Human Committee (CMDh), EMEA/CMDh/98694/2008:London, 27 February, 2008.

3. The Utility of Sulfonate Salts in Drug Development

4. Structure–activity considerations and in vitro approaches to assess the genotoxicity of 19 methane-, benzene- and toluenesulfonic acid esters

5. Salt formation to improve drug solubility

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