Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac-Reference-Cited by-同舟云学术

Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac

Published:1999-01-14 Issue:2 Volume:12 Page:214-222
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Shen Sijiu¹,Marchick Michael R.¹,Davis Margaret R.¹,Doss George A.¹,Pohl Lance R.¹

Affiliation:

1. Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx9802365

Reference53 articles.

1. Reversible Hepatitis Associated with Diclofenac

2. Diclofenac-induced hepatotoxicity.

Cited by 174 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Electrochemical Assessment of CYP3A4 Catalytic Activity in Bactosomes;BioNanoScience;2024-07-12

2. Antagonistic effects of a COX1/2 inhibitor drug in human HepG2 cells exposed to an environmental carcinogen;Environmental Toxicology and Pharmacology;2024-06

3. Diclofenac derivatives as promising anticancer and anti-inflammatory drug: Synthesis, formulations, and pharmacokinetics;Journal of Drug Delivery Science and Technology;2024-05

4. Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes;Archives of Toxicology;2024-03-23

5. Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview;Analytical Methods;2024