Role of Tyrosine 65 in the Mechanism of Serine Hydroxymethyltransferase-Reference-Cited by-同舟云学术

Role of Tyrosine 65 in the Mechanism of Serine Hydroxymethyltransferase

Published:2000-05-31 Issue:25 Volume:39 Page:7492-7500
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Contestabile Roberto¹,Angelaccio Sebastiana¹,Bossa Francesco¹,Wright H. Tonie¹,Scarsdale Neel¹,Kazanina Galina¹,Schirch Verne¹

Affiliation:

1. Dipartimento di Scienze Biochimiche “A. Rossi Fanelli” and Centro di Biologia Molecolare del Consiglio Nazionale delle Ricerche, Università La Sapienza, Roma, Italy, and Department of Biochemistry and Molecular Biophysics and The Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi000032z

Reference33 articles.

1. Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

2. Properties of a serine hydroxymethyltransferase in which an active site histidine has been changed to an asparagine by site-directed mutagenesis.

3. Escherichia coli serine hydroxymethyltransferase. The role of histidine 228 in determining reaction specificity.

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2;Biochemistry;2024-02-07

2. Universality of critical active site glutamate as an acid–base catalyst in serine hydroxymethyltransferase function;Chemical Science;2024

3. Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography;Communications Chemistry;2023-08-03

4. 4′-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity;Microbiology;2023-04-11

5. Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria;Angewandte Chemie International Edition;2022-11-17