Overcoming the Genotoxicity of a Pyrrolidine Substituted Arylindenopyrimidine As a Potent Dual Adenosine A2A/A1 Antagonist by Minimizing Bioactivation to an Iminium Ion Reactive Intermediate-Reference-Cited by-同舟云学术

Overcoming the Genotoxicity of a Pyrrolidine Substituted Arylindenopyrimidine As a Potent Dual Adenosine A2A/A1 Antagonist by Minimizing Bioactivation to an Iminium Ion Reactive Intermediate

Published:2011-06-28 Issue:7 Volume:24 Page:1012-1030
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Lim Heng-Keang¹,Chen Jie¹,Sensenhauser Carlo¹,Cook Kevin¹,Preston Robert¹,Thomas Tynisha¹,Shook Brian¹,Jackson Paul F.¹,Rassnick Stefanie¹,Rhodes Kenneth¹,Gopaul Vedwatee¹,Salter Rhys¹,Silva Jose¹,Evans David C.¹

Affiliation:

1. Drug Safety Sciences, ‡Medicinal Chemistry, and §Biology, Johnson and Johnson Pharmaceutical Research and Development, 1000 Route 202 South, New Jersey 08869, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx1004437

Reference36 articles.

1. Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

2. Revised methods for the Salmonella mutagenicity test

3. Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

4. Analysis of Crotonaldehyde- and Acetaldehyde-Derived 1,N2-Propanodeoxyguanosine Adducts in DNA from Human Tissues Using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

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