Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation-Reference-Cited by-同舟云学术

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

Published:2007-03-07 Issue:6 Volume:35 Page:848-858
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Kalgutkar Amit S.,Dalvie Deepak K.,Aubrecht Jiri,Smith Evan B.,Coffing Stephanie L.,Cheung Jennifer R.,Vage Chandra,Lame Mary E.,Chiang Phoebe,McClure Kim F.,Maurer Tristan S.,Coelho Richard V.,Soliman Victor F.,Schildknegt Klaas

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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3. Oxidation of eugenol to form DNA adducts and 8-hydroxy-2'- deoxyguanosine: role of quinone methide derivative in DNA adduct formation

4. Evidence That 4-Allyl-o-quinones Spontaneously Rearrange to Their More Electrophilic Quinone Methides: Potential Bioactivation Mechanism for the Hepatocarcinogen Safrole

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