Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport-Reference-Cited by-同舟云学术

Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport

Published:2005-03-16 Issue:2 Volume:2 Page:157-167
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Song Xueqin¹,Lorenzi Philip L.¹,Landowski Christopher P.¹,Vig Balvinder S.¹,Hilfinger John M.¹,Amidon Gordon L.¹

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, and TSRL, Inc., 540 Avis Drive, Suite A, Ann Arbor, Michigan 48108

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp049888e

Reference37 articles.

1. Clinical, toxicological and pharmacological aspects of gemcitabine

2. Preclinical characteristics of gemcitabine

Cited by 109 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Valacyclovir and Acyclovir Are Substrates of the Guanine Deaminase Cytosolic PSD‐95 Interactor (Cypin);Proteins: Structure, Function, and Bioinformatics;2024-08-29

2. A Novel Fluorescent Gemcitabine Prodrug That Follows a Nucleoside Transporter‐Independent Internalization and Bears Enhanced Therapeutic Efficacy With Respect to Gemcitabine;Chemistry – A European Journal;2024-08-19

3. Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug;ACS Omega;2024-07-09

4. Exploring the physicochemical properties of the integration of Tristearoyl uridine in Langmuir monolayers: An approach to cell membrane modeling for prodrugs;Biophysical Chemistry;2024-07

5. Coumarin–amino acid hybrids as promising anticancer agents: design, synthesis, docking studies and CK2 inhibition;RSC Advances;2024