Coumarin–amino acid hybrids as promising anticancer agents: design, synthesis, docking studies and CK2 inhibition-Reference-Cited by-同舟云学术

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Coumarin–amino acid hybrids as promising anticancer agents: design, synthesis, docking studies and CK2 inhibition

Published:2024 Issue:34 Volume:14 Page:24671-24686
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

El-Etrawy Abd-Allah S.¹²,Ramadan Ahmad³,Sherbiny Farag F.⁴^ORCID,Zeid I. F.³,Abdel-Rahman A. A.-H.³,Hawata Mohamed A.³

Affiliation:

1. Department of Chemistry, Basic Science Center, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

2. Department of Pharmaceutical Organic Chemistry College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

3. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt

4. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Abstract

A new series of amino acid derivatives linked to coumarin has been synthesized as CK2 inhibitors. Compound 7c outperforms doxorubicin in cell lines, while compound 5b shows superior CK2 inhibition compared to roscovetine.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04226C

Reference70 articles.

1. The global burden of cancer: priorities for prevention

2. Advances in nanomedicine for cancer starvation therapy

3. Heterocycles in Medicinal Chemistry

4. Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

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