Inhibiting AMPylation: A Novel Screen To Identify the First Small Molecule Inhibitors of Protein AMPylation

Author:

Lewallen Daniel M.1,Sreelatha Anju2,Dharmarajan Venkatasubramanian3,Madoux Franck4,Chase Peter4,Griffin Patrick R.3,Orth Kim2,Hodder Peter4,Thompson Paul R.15

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, Scripps Florida, 120 Scripps Way, Jupiter, Florida 33458, United States

2. Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas 75390, United States

3. Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 120 Scripps Way, Jupiter, Florida 33458, United States

4. Lead Identification, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, United States

5. The Kellogg School of Science and Technology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Reference32 articles.

1. Foodborne Illness Acquired in the United States—Major Pathogens

2. Centers for Disease Control and Prevention (CDC) (2010) Vital Signs: Incidence and Trends of Infection with Pathogens Transmitted Commonly Through Food—Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 1996–2010,MMWR. Morbidity and Mortality Weekly Reports, retrieved fromhttp://cdc.gov/mmwr/preview/mmwrhtml/mm6022a6025.htm?s_cid=mm6022a6025w.

3. AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

4. The Fic Domain: Regulation of Cell Signaling by Adenylylation

5. The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

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