1. School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom, Karus Therapeutics, Southampton SO17 1BJ, United Kingdom, Cancer Research UK Clinical Centre, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom, and Chemical Genetics Laboratory, RIKEN Discovery Research Institute, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan