High Lipophilicity of meta Mn(III) N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-Deficient Escherichia coli-Reference-Cited by-同舟云学术

High Lipophilicity of meta Mn(III) N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-Deficient Escherichia coli

Published:2009-07-21 Issue:23 Volume:52 Page:7868-7872
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kos Ivan¹,Benov Ludmil²,Spasojević Ivan³,Rebouças Júlio S.¹,Batinić-Haberle Ines¹

Affiliation:

1. Department of Radiation Oncology

2. Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait

3. Department of Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900576g

Reference32 articles.

1. Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: Protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier

2. Relationship among Redox Potentials, Proton Dissociation Constants of Pyrrolic Nitrogens, and in Vivo and in Vitro Superoxide Dismutating Activities of Manganese(III) and Iron(III) Water-Soluble Porphyrins

3. Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion

4. SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

5. Halliwell, B.; Gutterdige, J. M. C.Free Radicals in Biology and Medicine Biosciences;Oxford University Press:New York, 2007.

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