Chemical Reactivity of Methoxy 4-O-Aryl Quinolines: Identification of Glutathione Displacement Products in Vitro and in Vivo
Author:
Affiliation:
1. Pharmacokinetics and Drug Metabolism and Medicinal Chemistry, Amgen, Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx800307n
Reference25 articles.
1. Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development
2. Biological Reactive Intermediates in Drug Discovery and Development
3. Reactive metabolites and their role in drug reactions
4. Metabolic activation in drug allergies
Cited by 22 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Recent Advances in the Design and Synthesis of c-Met Inhibitors as Anticancer Agents (2014-Present);Current Medicinal Chemistry;2017-01-16
2. Discovery of AMG 337: Using Structure Guided Scaffold Hybridization to Optimize Physicochemical Properties and Target Coverage of a MET Kinase Inhibitor;Comprehensive Medicinal Chemistry III;2017
3. Detecting reactive drug metabolites for reducing the potential for drug toxicity;Expert Opinion on Drug Metabolism & Toxicology;2015-05-25
4. Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors;Journal of Medicinal Chemistry;2015-03-03
5. Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors;Bioorganic & Medicinal Chemistry Letters;2014-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3