PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration-Reference-Cited by-同舟云学术

PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration

Published:2015-02-18 Issue:3 Volume:12 Page:794-809
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Chan Linda J.¹,Bulitta Jürgen B.¹,Ascher David B.²,Haynes John M.³,McLeod Victoria M.¹,Porter Christopher J. H.¹,Williams Charlotte C.⁴,Kaminskas Lisa M.¹

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Department of Biochemistry, University of Cambridge, Sanger Building, Downing Site, Cambridge, CB2 1GA, U.K.

3. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

4. CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp5006189

Reference66 articles.

1. Therapeutic antibodies: successes, limitations and hopes for the future

2. Development trends for human monoclonal antibody therapeutics

3. Adjuvant Trastuzumab in HER2-Positive Breast Cancer

4. Trastuzumab

5. Trastuzumab

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