RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake <i>In Vivo</i>-Reference-Cited by-同舟云学术

RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo

Published:2023-05-23 Issue:6 Volume:20 Page:3073-3087
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ardana Aditya¹,Ghosh Saikat²³^ORCID,Huda Pie²^ORCID,Fletcher Nicholas L.²^ORCID,Thurecht Kristofer J.²³^ORCID,Williams Charlotte C.¹^ORCID

Affiliation:

1. Commonwealth Scientific and Industrial Research Organization Manufacturing, Bayview Avenue, Clayton, Melbourne, Victoria 3168, Australia

2. Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland, Brisbane, St Lucia, Queensland, 4072, Australia

3. Australian Research Council Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, St Lucia, Queensland 4072, Australia

Funder

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00085

Reference32 articles.

1. Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

2. A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

3. Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

4. Self-assembly of protein-polymer conjugates for drug delivery

5. Polymer Based Protein Therapeutics

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1. RAFT Polymer−Antibody Conjugation of a Therapeutic Anti-EGFR Antibody to Increase Tumor Uptake In Vivo;Synfacts;2023-07-14