In silico Prediction of Total Human Plasma Clearance-Reference-Cited by-同舟云学术

In silico Prediction of Total Human Plasma Clearance

Published:2012-07-18 Issue:8 Volume:52 Page:2069-2078
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Berellini Giuliano¹,Waters Nigel J.¹,Lombardo Franco¹

Affiliation:

1. Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge Massachusettes 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci300155y

Reference46 articles.

1. Animal scale-up

2. Prediction of Human Clearance from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis

3. A COMPREHENSIVE QUANTITATIVE AND QUALITATIVE EVALUATION OF EXTRAPOLATION OF INTRAVENOUS PHARMACOKINETIC PARAMETERS FROM RAT, DOG, AND MONKEY TO HUMANS. I. CLEARANCE

4. Allometric scaling of pharmacokinetic parameters in drug discovery: Can human CL, Vss and t1/2 be predicted fromin-vivo rat data?

5. A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans

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