Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides-Reference-Cited by-同舟云学术

Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides

Published:2010-11-08 Issue:23 Volume:53 Page:8309-8318
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Seth Punit P.¹,Allerson Charles R.¹,Siwkowski Andrew²,Vasquez Guillermo¹,Berdeja Andres³,Migawa Michael T.¹,Gaus Hans³,Prakash Thazha P.¹,Bhat Balkrishen¹,Swayze Eric E.¹

Affiliation:

1. Department of Medicinal Chemistry

2. Antisense Drug Discovery

3. Structural Biology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101207e

Reference47 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

3. Rational design of cationic lipids for siRNA delivery

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