Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition-Reference-Cited by-同舟云学术

Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition

Published:2006-03-11 Issue:8 Volume:71 Page:3086-3092
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Scott Jeremy P.¹,Oliver Steven F.¹,Brands Karel M. J.¹,Brewer Sarah E.¹,Davies Antony J.¹,Gibb Andrew D.¹,Hands David¹,Keen Stephen P.¹,Sheen Faye J.¹,Reamer Robert A.¹,Wilson Robert D.¹,Dolling Ulf-H.¹

Affiliation:

1. Department of Process Research, Merck Sharp & Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, United Kingdom, and Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo060033i

Reference29 articles.

1. β-Amyloid therapies in Alzheimer’s disease

2. Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

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