Mechanism-Based Inhibition of iPLA2β Demonstrates a Highly Reactive Cysteine Residue (C651) That Interacts with the Active Site: Mass Spectrometric Elucidation of the Mechanisms Underlying Inhibition
Author:
Affiliation:
1. Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi4004233
Reference55 articles.
1. Phospholipase A2 enzymes
2. Properties of the Group IV phospholipase A2 family
3. Role of Ca2+-independent phospholipase A2 in cell growth and signaling
4. The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids
5. Eicosanoid signalling pathways in the heart
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