Live-cell imaging reveals impaired detoxification of lipid-derived electrophiles is a hallmark of ferroptosis-Reference-Cited by-同舟云学术

Live-cell imaging reveals impaired detoxification of lipid-derived electrophiles is a hallmark of ferroptosis

Published:2022 Issue:33 Volume:13 Page:9727-9738
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Van Kessel Antonius T. M.¹^ORCID,Karimi Ryan¹^ORCID,Cosa Gonzalo¹^ORCID

Affiliation:

1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada

Abstract

A link between altered lipid-derived electrophile (LDE) metabolism during ferroptosis and associated cell death was uncovered using a new imaging method developed to monitor cellular LDE detoxification that employs a fluorogenic LDE analogue.

Funder

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00525E

Reference58 articles.

1. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

2. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

3. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

4. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

5. Synchronized renal tubular cell death involves ferroptosis

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