1. Synthetic Technology Research Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-Ku, Tokyo 115-8543, Japan, Chemistry Research Department I, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan, and Fujieda Plant, Chugai Pharmaceutical Co., Ltd., 2500 Takayanagi, Fujieda, Shizuoka 426-0041, Japan