Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor-Reference-Cited by-同舟云学术

Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor

Published:2018 Issue:14 Volume:16 Page:2448-2455
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sawada Daisuke¹²³⁴,Kakuda Shinji⁵⁶⁷⁴,Takeuchi Akiko⁵⁶⁷⁴,Kawagoe Fumihiro¹²³⁴,Takimoto-Kamimura Midori⁵⁶⁷⁴,Kittaka Atsushi¹²³⁴^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Teikyo University

3. Tokyo 173-8605

4. Japan

5. Teijin Institute for Bio-medical Research

6. Teijin Pharma Ltd

7. Hino

Abstract

Interaction of the 2-functional group of tachysterol analogs in the vitamin D receptor ligand binding domain: X-ray co-crystallographic analysis.

Funder

Japan Society for the Promotion of Science

Uehara Memorial Foundation

Takeda Science Foundation

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00158H

Reference32 articles.

1. Synthetic Studies of Vitamin D Analogues. XIV. Synthesis and Calcium Regulating Activity of Vitamin D3 Analogues Bearing a Hydroxyalkoxy Group at the 2.BETA.-Position.

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3. Diverse and Important Contributions by Medicinal Chemists to the Development of Pharmaceuticals: An Example of Active Vitamin D3 Analog, Eldecalcitol

4. A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures — A randomized, active comparator, double-blind study

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