1. Departments of Medicinal Chemistry, Chemical Technologies, Structural Chemistry, Assay Development and Screening, Preclinical R&D, and Biology, Biovitrum, Box 6443, SE-751 37, Uppsala, Sweden, and Computational Chemistry, BioFocus, 130 Abbott Drive, Sittingbourne Research Centre, Sittingbourne, Kent ME9 8AZ, U.K.