Discovery of 1′-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3′-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach

Author:

Zhang Colin,Xu Meizhong,He Chunhong,Zhuo Jincong,Burns David M.,Qian Ding-Quan,Lin Qiyan,Li Yun-Long,Chen Lihua,Shi Eric,Agrios Costas,Weng Linkai,Sharief Vaqar,Jalluri Ravi,Li Yanlong,Scherle Peggy,Diamond Sharon,Hunter Deborah,Covington Maryanne,Marando Cindy,Wynn Richard,Katiyar Kamna,Contel Nancy,Vaddi Kris,Yeleswaram Swamy,Hollis Gregory,Huber Reid,Friedman Steve,Metcalf Brian,Yao Wenqing

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference39 articles.

1. Diabetes fact sheets. World Health Organization website. https://www.who.int/news-room/fact-sheets/detail/diabetes Published June 8, 2020. Accessed March 26, 2020.

2. National diabetes fact sheet. Centers for Disease Control and Prevention website. https://www.cdc.gov/chronicdisease/resources/publications/factsheets/diabetes-prediabetes.htm. Updated November 3, 2020. Accessed March 26, 2020.

3. (a) Diabetes: success and opportunities for population-based prevention and control: at a glance 2010. Centers for Disease Control and Prevention website. https://www.cdc.gov/chronicdisease/resources/publications/aag/diabetes.htm. Accessed March 26, 2020. (b) Bays HE, Chapman RH, Grandy S, The SHIELD Investigators’ Group. The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys. Int J Clin Pract. 2007, 61, 737–747. doi: 10.1111/j.1742-1241.2007.01336.x.

4. The metabolic syndrome;Cornier;Endocr Rev,2008

5. Tissue-specific Cushing’s syndrome, 11β-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action;Stewart;Eur J Endocrinol,2003

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